Article
Linkage analysis in dominantly inherited osteogenesis imperfecta.
American journal of medical genetics - 15 Jan 1993
Sykes B
Abstract excerpt
The only serious attempts at linkage in osteogenesis imperfecta (OI) have shown that the disease is linked to type 1 collagen genes in all families studied in which it segregrates as a clear mendelian dominant trait. For prenatal diagnosis the probability that a new family is linked can be taken...
Topics
- Alleles
- Collagen
- Genes, Dominant
- Genetic Linkage
- Humans
- Osteogenesis Imperfecta
- Pedigree