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Article

Linkage analysis in dominantly inherited osteogenesis imperfecta.

American journal of medical genetics - 15 Jan 1993

Sykes B

Abstract excerpt

The only serious attempts at linkage in osteogenesis imperfecta (OI) have shown that the disease is linked to type 1 collagen genes in all families studied in which it segregrates as a clear mendelian dominant trait. For prenatal diagnosis the probability that a new family is linked can be taken as greater than 0.95 and this figure is augmented as more meioses are studied. Some phenotype correlations, notably...

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Identifiers

PMID: 8456805
DOI: 10.1002/ajmg.1320450212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage analysis in dominantly inherited osteogenesis imperfecta.PMID 8456805Read ↗

Consistent linkage of dominantly inherited osteogenesis imperfecta to the type I collagen loci: COL1A1 and COL1A2.Semantic proximity Read ↗

Strategy for prenatal diagnosis of osteogenesis imperfecta by linkage analysis to the type I collagen loci COL1A1 and COL1A2.Semantic proximity Read ↗

Prenatal diagnosis of osteogenesis imperfecta by identification of the concordant collagen 1 allele.Semantic proximity Read ↗

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Investigation of chromosome 2q in osteoarthritis of the hand: no significant linkage in a Tasmanian population.Semantic proximity Read ↗

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Localization of a gene for autosomal dominant amelogenesis imperfecta (ADAI) to chromosome 4q.Semantic proximity Read ↗

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