FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes.

doi:10.1016/0014-5793(93)81297-d

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Article

FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes.

FEBS letters - 1 Feb 1993

Sener A, Herberg L, Malaisse W J

Abstract excerpt

The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase plays a key role in the glucose-sensing device of the insulin-producing pancreatic B-cell. Its activity was found to be decreased in islet, but not liver, homogenates of BL/Ks-db/db mice, in which diabetes mellitus represents an i...

Topics

Animals
Diabetes Mellitus, Experimental
Flavin-Adenine Dinucleotide
Genotype
Glycerolphosphate Dehydrogenase
Islets of Langerhans
Mice
Mice, Mutant Strains

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