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Article

Excess histidine enzymes cause AICAR-independent filamentation in Escherichia coli.

Molecular & general genetics : MGG - 1 Sept 1993

Frandsen N, D'Ari R

Abstract excerpt

High-level expression of the hisHAFI genes in Escherichia coli, cloned under the control of an IPTG-inducible promoter, caused filamentation, as previously reported in Salmonella typhimurium. We speculated that this filamentation might be produced by an action of the HisH and HisF enzymes on their product AICAR (amino-imidazole carboxamide riboside 5'-phosphate), a histidine by-product and normal purine...

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PMID: 8413183
DOI: 10.1007/BF00280385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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