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The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants.

The Journal of biological chemistry - 15 Oct 1993

Sirawaraporn W, Prapunwattana P, Sirawaraporn R, Yuthavong Y, Santi D V

Abstract excerpt

A 693-base pair gene coding for the 27,132-dalton dihydrofolate reductase (DHFR) domain of the thymidylate synthase-dihydrofolate reductase (TS-DHFR) bifunctional protein of Plasmodium falciparum was designed to have Escherichia coli codon preference and multiple unique restriction sites and was...

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Mutation
Molecular Sequence Data
Base Sequence
Amino Acid Sequence
Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Escherichia coli

Drug Resistance

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Identifiers

PMID: 8408015

Genes

DHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8408015-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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