Article
Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.
Molecular and biochemical parasitology - 2 Dec 1996
Prapunwattana P, Sirawaraporn W, Yuthavong Y, Santi D V
Abstract excerpt
Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-known target for pyrimethamine and cycloguanil. The low amounts of enzyme obtainable from parasites or the currently available heterologous expression systems have thus far hindered studies of this enzyme. The 1912-base pair P. falciparum DHFR-TS gene was designed based on E. coli codon preference with unique restriction sites...
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