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Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

Molecular and biochemical parasitology - 2 Dec 1996

Prapunwattana P, Sirawaraporn W, Yuthavong Y, Santi D V

Abstract excerpt

Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-known target for pyrimethamine and cycloguanil. The low amounts of enzyme obtainable from parasites or the currently available heterologous expression systems have thus far hindered studies of this enzyme. The...

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Mutation
Molecular Sequence Data
Escherichia coli
Restriction Mapping
Kinetics
Species Specificity

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Recombinant Proteins

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PMID: 9010845
DOI: 10.1016/s0166-6851(96)02756-9

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DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9010845-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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