Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.

Gene - 30 Sept 1993

Mattheakis L C, Sor F, Collier R J

Abstract excerpt

A gene involved in diphthamide biosynthesis, DPH2, was cloned from Saccharomyces cerevisiae by complementation of a diphthamide mutant. DPH2 exists as a single-copy gene in the yeast genome and is located on the left arm of chromosome XI. Sequence analysis of the DPH2 locus predicts that the DPH2 gene product is a 534-amino acid (aa) protein, with a calculated M(r) of 59,772. This conclusion was supported by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Escherichia coli

Share to Molecular Sequence Data

Share to Mutation

Share to RNA, Messenger

Source

Identifiers

PMID: 8406038
DOI: 10.1016/0378-1119(93)90528-b

Genes

DPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.PMID 8406038Read ↗

DPH1 and DPH2 variants that confer susceptibility to diphthamide deficiency syndrome in human cells and yeast models.Semantic proximity Read ↗

DPB2, the gene encoding DNA polymerase II subunit B, is required for chromosome replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.Semantic proximity Read ↗

The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability.Semantic proximity Read ↗

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.Semantic proximity Read ↗

Functional Integrity of Radical SAM Enzyme Dph1•Dph2 Requires Non-canonical Cofactor Motifs with Tandem CysteinesSemantic proximity Read ↗

DPH1 Gene Mutations Identify a Candidate SAM Pocket in Radical Enzyme Dph1•Dph2 for Diphthamide Synthesis on EF2.Semantic proximity Read ↗

The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network.Semantic proximity Read ↗

Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Insights into diphthamide, key diphtheria toxin effector.Semantic proximity Read ↗

Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes.Semantic proximity Read ↗

A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.