Article
A cell-surface molecule involved in organ-specific homing of lymphocytes.
Nature - 1 Jan 2000
Gallatin W M, Weissman I L, Butcher E C
Abstract excerpt
Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.
Topics
- Animals
- Antibodies, Monoclonal
- Antigen-Antibody Complex
- Antigens, Surface
- Cell Adhesion
- Cell Line
- Endothelium
- Humans
- Lymphocytes
- Lymphoma
- Mice
- Molecular Weight