Article
Genes necessary for expression of a virulence determinant and for transmission of Plasmodium falciparum are located on a 0.3-megabase region of chromosome 9.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1993
Day K P, Karamalis F, Thompson J, Barnes D A, Peterson C, Brown H, Brown G V, Kemp D J
Abstract excerpt
Virulence of the human malaria parasite Plasmodium falciparum is believed to relate to adhesion of parasitized erythrocytes to postcapillary venular endothelium (asexual cytoadherence). Transmission of malaria to the mosquito vector involves a switch from asexual to sexual development (gametocytogenesis). Continuous in vitro culture of P. falciparum frequently results in irreversible loss of asexual cytoadherence...
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