Article
Regional distributions of beta-thalassemia mutations in Turkey.
International journal of hematology - 1 Jun 1993
Atalay E O, Cirakoğlu B, Dinçolç G, Atalay A, Kilinç Y, Aytekin H, Yüregir G T, Arpaci A, Bermek E, Aksoy M
Abstract excerpt
The distributions of twelve beta-thalassemic mutations in samples (n = 139 chromosomal samples) from four regions of Turkey were determined. The frequencies of these mutations did not reveal a notable region specific heterogeneity. In particular, the four mutations, IVS.1/nt.110(G/A), IVS.1/nt.6(T/C), IVS.1/nt.1(G/A) and nonsense codon.39(C/T), with country-scale frequencies of 35.9%, 21.6%, 13.0% and 7.2%,...
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