Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigen presentation, loss of immunological memory and AIDS.

Immunology today - 1 Jul 1993

Helbert M R, L'age-Stehr J, Mitchison N A

Abstract excerpt

A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD45RO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to Acquired Immunodeficiency Syndrome
Share to Antigen-Presenting Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Leukocyte Common Antigens

Share to Lymphocyte Activation

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 8363722
DOI: 10.1016/0167-5699(93)90232-A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Antigen presentation, loss of immunological memory and AIDS.PMID 8363722Read ↗

HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T CellsSemantic proximity Read ↗

Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

CD45RA+ T cells: not simple virgins.Semantic proximity Read ↗

Altered lymphocyte antigen expressions in HIV infection: a study by quantitative flow cytometry.Semantic proximity Read ↗

Selective loss of T cell functions in different stages of HIV infection. Early loss of anti-CD3-induced T cell proliferation followed by decreased anti-CD3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS.Semantic proximity Read ↗

Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesis.Semantic proximity Read ↗

CD4 T helper lymphocytes and antigen presenting cells in the physiopathology of AIDS.Semantic proximity Read ↗

Striking a Balance—Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic StimulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.