Article
Up-regulation of ETB receptor subtype mRNA by angiotensin II in rat cardiomyocytes.
Biochemical and biophysical research communications - 16 Aug 1993
Kanno K, Hirata Y, Tsujino M, Imai T, Shichiri M, Ito H, Marumo F
Abstract excerpt
The effect of angiotensin (ANG) II on the expression of endothelin (ET) receptor subtype (ETA, ETB) mRNA in cultured neonatal rat cardiomyocytes was studied. ANG II (10(-7) M) increased steady-state mRNA levels of ETB receptor, but not ETA receptor, during 6-12 hr incubation, whose effect was dose-dependent (10(-9)-10(-7) M). ANG II receptor type-1 (AT1) antagonist (CV-11974) completely inhibited the ANG...
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