The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.

doi:10.1016/0047-6374(93)90135-e

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Article

The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.

Mechanisms of ageing and development - 1 May 1993

Ishi N, Suzuki N, Hartman P S, Suzuki K

Abstract excerpt

A mutant of rad-8, originally isolated on the basis of its hypersensitivity to ultraviolet radiation, is also hypersensitive to oxygen and methyl viologen, a superoxide-anion generator. Oxygen also retarded development and reduced fecundity in a concentration-dependent fashion in rad-8 but not in...

Topics

Aging
Animals
Caenorhabditis elegans
Fertility
Longevity
Mutation
Oxygen
Paraquat
Radiation Tolerance
Survival Rate

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