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Article

Polypeptide variants of beta-arrestin and arrestin3.

The Journal of biological chemistry - 25 Jul 1993

Sterne-Marr R, Gurevich V V, Goldsmith P, Bodine R C, Sanders C, Donoso L A, Benovic J L

Abstract excerpt

Retinal arrestin (S-antigen) inactivates the phototransduction cascade by binding to light-activated phosphorylated rhodopsin and thereby "arresting" coupling to the G protein transducin. beta-Arrestin (beta arr), a ubiquitous arrestin homolog, acts analogously to desensitize the beta 2-adrenergic receptor by disrupting Gs receptor interaction. In an attempt to identify additional "arrestins" which might regulate...

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PMID: 8340388

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