Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Human Factor IX by Microencapsulated Recombinant Fibroblasts

1 Jun 1993

Abstract excerpt

Deficiency of clotting factor IX (FIX) causes hemophilia B in humans. We propose a novel approach to its treatment by engineering FIX-secreting cell lines suitable for implantation in different allogeneic hosts. To prevent graft rejection following implantation, the recombinant cells can be protected with biocompatible membranes that permit exit of FIX but not entry of cellular immune mediators. To explore the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Pancreatic function and diabetes
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8338876
DOI: 10.1089/hum.1993.4.3-291

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Expression of Human Factor IX by Microencapsulated Recombinant FibroblastsPMID 8338876Read ↗

Treatment of a lysosomal storage disease, mucopolysaccharidosis VII, with microencapsulated recombinant cells.Semantic proximity Read ↗

Oral gene therapy for hemophilia B using chitosan-formulated FIX mutants.Semantic proximity Read ↗

Retrovirus vector-mediated correction and cross-correction of lysosomal alpha-mannosidase deficiency in human and feline fibroblasts.Semantic proximity Read ↗

Several Log Increase in Therapeutic Transgene Delivery by Distinct Adeno-Associated Viral Serotype VectorsSemantic proximity Read ↗

Therapeutic Levels of Factor IX Expression Using a Muscle-Specific Promoter and Adeno-Associated Virus Serotype 1 VectorSemantic proximity Read ↗

Cloning and recombinant expression of mouse coagulation factor X.Semantic proximity Read ↗

Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts.Semantic proximity Read ↗

Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs.Semantic proximity Read ↗

Human Endothelial Cells And Fibroblasts Express And Produce The Coagulation Proteins Necessary For Thrombin GenerationSemantic proximity Read ↗

In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factorSemantic proximity Read ↗

In vitro study of encapsulation therapy for Fabry disease using genetically engineered CHO cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.