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Article

Several Log Increase in Therapeutic Transgene Delivery by Distinct Adeno-Associated Viral Serotype Vectors

1 Dec 2000

Abstract excerpt

We previously demonstrated that rAAV vectors carrying human and canine factor IX (FIX) cDNA can infect, stably persist, and secrete functional human and canine FIX following direct intramuscular injection. In an attempt to improve FIX protein secretion for eventual therapeutic use, we set out to determine if alteration of the AAV capsid would affect skeletal muscle transduction and factor IX secretion. Two...

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Identifiers

PMID: 11124063
DOI: 10.1006/mthe.2000.0219

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Several Log Increase in Therapeutic Transgene Delivery by Distinct Adeno-Associated Viral Serotype VectorsPMID 11124063Read ↗

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