Cytogenetically different leukemic clones at relapse of childhood acute lymphoblastic leukemia

Abstract excerpt

Sequential analysis of blast cell chromosomes in 98 cases of acute lymphoblastic leukemia (ALL) disclosed entirely different karyotypes for nine patients at the time of relapse. The presenting clinical, immunophenotypic, and cytogenetic features of this subgroup were similar to those of the 89 patients without major karyotypic shifts. The median length of initial remissions in these nine patients, all of whom...

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