Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

doi:10.1002/pro.5560041004

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Article

Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.

Protein science : a publication of the Protein Society - 1 Oct 1995

Huang K, Lu W, Anderson S, Laskowski M, James M N

Abstract excerpt

Crystal structures of the complexes of Streptomyces griseus proteinase B (SGPB) with three P1 variants of turkey ovomucoid inhibitor third domain (OMTKY3), Leu18, Ala18, and Gly18, have been determined and refined to high resolution. Comparisons among these structures and of each with native, unc...

Topics

Alanine
Amino Acid Sequence
Animals
Binding Sites
Calorimetry
Coturnix
Crystallography, X-Ray
Genetic Variation
Glycine
Hydrogen Bonding
Leucine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Ovomucin

Point Mutation

Protein Conformation

Recombinant Proteins

Serine Endopeptidases

Streptomyces griseus

Source

Open in PubMed Open full text

Identifiers

PMID: 8535235
DOI: 10.1002/pro.5560041004
PMCID: PMC2142981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8535235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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