Article
Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature.
The Journal of clinical investigation - 1 Jan 1994
Elices M J, Tsai V, Strahl D, Goel A S, Tollefson V, Arrhenius T, Wayner E A, Gaeta F C, Fikes J D, Firestein G S
Abstract excerpt
Expression of fibronectin (FN) isoforms containing CS1, a 25-amino acid sequence present within the alternatively spliced IIICS region of FN, has been analyzed in rheumatoid arthritis (RA) synovium. Unexpectedly, CS1-containing FN variants were exclusively found on endothelium but not extracellul...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
- Cell Adhesion
- Cell Line
- Endothelium, Vascular
- Fibronectins
- Genetic Variation
- Humans
- Immunoenzyme Techniques
- Mice
- Mice, Inbred BALB C