Article
Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature.
The Journal of clinical investigation - 1 Jan 1994
Elices M J, Tsai V, Strahl D, Goel A S, Tollefson V, Arrhenius T, Wayner E A, Gaeta F C, Fikes J D, Firestein G S
Abstract excerpt
Expression of fibronectin (FN) isoforms containing CS1, a 25-amino acid sequence present within the alternatively spliced IIICS region of FN, has been analyzed in rheumatoid arthritis (RA) synovium. Unexpectedly, CS1-containing FN variants were exclusively found on endothelium but not extracellular matrix (ECM) of RA synovium. Lumenal expression of CS1 on RA endothelial cells, as observed by electron microscopy,...
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