Regulation of alternative splicing in the IIICS region of human fibronectin pre-mRNA encoding cell binding sites CS1 and CS5.

Abstract excerpt

The cell binding sites CS1 and CS5 in the IIICS region of human fibronectin (FN) mediate the adhesion of specific cell types by interacting with the integrin alpha 4 beta 1. IIICS pre-mRNA is alternatively spliced via the use of three alternative splice acceptor sites and one alternative splice donor site. These alternative splicing pathways can potentially give rise to variant FN molecules which are CS1+,CS5+;...

Topics

• Base Sequence
• Binding Sites
• Exons
• Fibronectins
• Gene Expression Regulation
• HeLa Cells
• Humans
• Introns
• Molecular Sequence Data
• Mutation
• Oligonucleotide Probes
• Plasmids