Article
T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint.
Clinical and experimental immunology - 1 Sept 1992
Rodriguez R M, Pitzalis C, Kingsley G H, Henderson E, Humphries M J, Panayi G S
Abstract excerpt
The accumulation of T cells within the joint is responsible for the perpetuation of synovitis. This process is partly regulated by selective binding to endothelium. However, adhesion to extra-cellular matrix proteins, like FN, may also be important. FN binding is mediated by certain members of th...
Topics
- Arthritis, Rheumatoid
- Cell Adhesion
- Fibronectins
- Fluorescent Antibody Technique
- Humans
- Integrins
- Lymphocyte Activation
- Phenotype
- Receptors, Very Late Antigen
- T-Lymphocytes
- T-Lymphocytes, Helper-Inducer