Article
Hepatitis C virus genotypes: an investigation of type-specific differences in geographic origin and disease.
Hepatology (Baltimore, Md.) - 1 Jan 1994
Dusheiko G, Schmilovitz-Weiss H, Brown D, McOmish F, Yap P L, Sherlock S, McIntyre N, Simmonds P
Abstract excerpt
Because of the nucleotide sequence diversity of different isolates of hepatitis C virus, it has become important to clarify whether distinct genotypes of hepatitis C virus vary with respect to pathogenicity, infectivity, response to antiviral therapy and geographic clustering. We assessed nucleotide sequence variability in the 5' noncoding region of hepatitis C virus, using restriction enzymes to analyze the...
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