Article
Recombinant cytokines as immunological adjuvants.
Immunology and cell biology - 1 Oct 1993
Nash A D, Lofthouse S A, Barcham G J, Jacobs H J, Ashman K, Meeusen E N, Brandon M R, Andrews A E
Abstract excerpt
This paper describes the bacterial expression and purification of bioactive recombinant ovine interleukin-2 (rovIL-2), interleukin-1 alpha (rovIL-1 alpha) and tumour necrosis factor alpha. These purified proteins had specific activities in appropriate bioassays of 1 x 10(7) 1 x 10(7) and 1 x 10(5) U/mg, respectively. Recombinant ovIL-1 alpha was assessed as an immunological adjuvant for the sheep response to the...
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