Article
The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1993
Chua S C, Hennessey K, Zeitler P, Leibel R L
Abstract excerpt
The little (lit) autosomal recessive mutation in the mouse causes dwarfism due to isolated growth hormone deficiency. The in vitro physiology of pituitary growth hormone release in lit/lit animals suggests that an abnormality in the growth hormone releasing factor (GRF) receptor (Ghrfr) is a very...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Dwarfism, Pituitary
- Female
- Growth Hormone
- Humans
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Receptors, Neuropeptide
- Receptors, Pituitary Hormone-Regulating Hormone