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Article

The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1993

Chua S C, Hennessey K, Zeitler P, Leibel R L

Abstract excerpt

The little (lit) autosomal recessive mutation in the mouse causes dwarfism due to isolated growth hormone deficiency. The in vitro physiology of pituitary growth hormone release in lit/lit animals suggests that an abnormality in the growth hormone releasing factor (GRF) receptor (Ghrfr) is a very likely candidate for the lit mutation. We mapped Ghrfr to the region around lit on Chromosome (Chr) 6 in 100...

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Identifiers

PMID: 8268652
DOI: 10.1007/BF00361384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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