Article
GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function.
Nature genetics - 1 Jul 1993
Godfrey P, Rahal J O, Beamer W G, Copeland N G, Jenkins N A, Mayo K E
Abstract excerpt
The growth hormone-releasing hormone receptor (GHRHR) is a member of the family of G protein-coupled receptors that is expressed on pituitary somatotrope cells and mediates the actions of GHRH in stimulating growth hormone (GH) synthesis and secretion. We report that the Ghrhr gene is located in the middle of mouse chromosome 6 in the same region as the little mutation. Mice homozygous for this mutation have...
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