Article
Functional characterization of a variant prekallikrein (PK Zürich).
Thrombosis and haemostasis - 1 Sept 1993
Wuillemin W A, Furlan M, von Felten A, Lämmle B
Abstract excerpt
The plasma of a 68-year-old man with cross reacting material (CRM)-positive prekallikrein (PK) deficiency was studied. PK clotting activity was < 0.01 U/ml, and PK antigen was 0.1 U/ml. No circulating anticoagulant against PK was detectable. The abnormal PK molecule, denoted as prekallikrein Zürich, was partially characterized by immunological and functional studies on the propositus' plasma. Immunoblotting...
Topics
- Aged
- Dextran Sulfate
- Factor XII
- Genetic Variation
- Humans
- Immunoblotting
- Kininogens
- Male
- Molecular Weight
- Prekallikrein