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Article

Heteroplasmy in Leber's hereditary optic neuropathy.

Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Nov 1993

Smith K H, Johns D R, Heher K L, Miller N R

Abstract excerpt

OBJECTIVES: To determine the incidence and clinical significance of peripheral blood heteroplasmy and the presence of normal and mutant mitochondrial DNA in Leber's hereditary optic neuropathy through evaluation of a large series of families with the 11778 mutation and to evaluate the pattern of transmission of heteroplasmy. DESIGN: We studied heteroplasmy in 75 visually symptomatic patients with the 11778...

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Identifiers

PMID: 8240102
DOI: 10.1001/archopht.1993.01090110052022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Heteroplasmy in Leber's hereditary optic neuropathy.PMID 8240102Read ↗

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