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Article

The unique characteristics of Thai Leber hereditary optic neuropathy: analysis of 30 G11778A pedigrees.

Journal of human genetics - 1 Jan 2006

Phasukkijwatana Nopasak, Chuenkongkaew Wanicha L, Suphavilai Rungnapa, Suktitipat Bhoom, Pingsuthiwong Sarinee, Ruangvaravate Ngamkae, Atchaneeyasakul La-Ongsri, Warrasak Sukhuma, Poonyathalang Anuchit, Sura Thanyachai, Lertrit Patcharee

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral visual loss, and affects mostly young males. The most common mitochondrial DNA mutation responsible for LHON worldwide is G11778A. Despite different genetic backgrounds, which are believed to influence the disease expression, most features of LHON are quite common in different populations. However, there seem to be a few...

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PMID: 16477364
DOI: 10.1007/s10038-006-0361-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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