Article
Novel, plasmid-encoded, TEM-derived extended-spectrum beta-lactamase in Klebsiella pneumoniae conferring higher resistance to aztreonam than to extended-spectrum cephalosporins.
Antimicrobial agents and chemotherapy - 1 Sept 1993
Arlet G, Rouveau M, Fournier G, Lagrange P H, Philippon A
Abstract excerpt
A clinical isolate of Klebsiella pneumoniae was more resistant to aztreonam than to cefotaxime and ceftazidime. It produced a clavulanate-susceptible beta-lactamase with an isoelectric point of 6.3 which readily hydrolyzed penicillins, cefotaxime, and ceftazidime, but which hydrolyzed aztreonam p...
Topics
- Anti-Bacterial Agents
- Aztreonam
- Cephalosporins
- DNA Probes
- DNA, Bacterial
- Humans
- Isoelectric Focusing
- Kinetics
- Klebsiella Infections
- Klebsiella pneumoniae
- Phenotype
- Plasmids
- beta-Lactamase Inhibitors
- beta-Lactamases