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Article

Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.

Antimicrobial agents and chemotherapy - 1 Dec 2003

Yigit Hesna, Queenan Anne Marie, Rasheed J Kamile, Biddle James W, Domenech-Sanchez Antonio, Alberti Sebastian, Bush Karen, Tenover Fred C

Abstract excerpt

We investigated a Klebsiella oxytoca isolate demonstrating resistance to imipenem, meropenem, extended-spectrum cephalosporins, and aztreonam. The MICs of both imipenem and meropenem were 32 microg/ml. The beta-lactamase activity against imipenem and meropenem was inhibited in the presence of clavulanic acid. Isoelectric focusing studies demonstrated five beta-lactamases with pIs of 8.2 (SHV-46), 6.7 (KPC-2), 6.5...

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Identifiers

PMID: 14638498
DOI: 10.1128/AAC.47.12.3881-3889.2003
PMCID: PMC296202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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