Possible reversal of ageing and other mitochondrial deficiencies through retroviral transfection of mitochondrially encoded proteins to the nucleus.

doi:10.1016/0306-9877(93)90058-x

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Possible reversal of ageing and other mitochondrial deficiencies through retroviral transfection of mitochondrially encoded proteins to the nucleus.

Medical hypotheses - 1 Aug 1993

Hoeben P

Abstract excerpt

This paper puts forward the hypothesis that ageing processes and a number of mitochondrially related diseases can be reversed or cured respectively. It briefly discusses the role of the mitochondrial genome in ageing and a number of inherited and age-related diseases. A rationale is then suggested which involves the utilization of retroviruses in translocating mitochondrial encoded proteins to the nucleus....

Topics

Aging
Animals
Cell Nucleus
Gene Deletion
Humans
Mammals
Mitochondria
Mitochondrial Encephalomyopathies
Models, Biological
Phenotype
Protein Biosynthesis
Proteins

Retroviridae

Transfection

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