The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease.

doi:10.1016/s0168-8278(05)80275-2

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Article

The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease.

Journal of hepatology - 1 Jul 1993

Faber J P, Poller W, Olek K, Baumann U, Carlson J, Lindmark B, Eriksson S

Abstract excerpt

Alpha 1-antichymotrypsin (alpha 1-ACT) is a serine proteinase inhibitor (serpin) with cathepsin G, mast cell chymase and chymotrypsin as target enzymes. We present the case of a middle-aged man with low plasma levels of alpha 1-ACT, asthma with progression to emphysema, and chronic HCV positive l...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA
Emphysema
Family Health
Hepatitis C
Heterozygote
Humans
Image Processing, Computer-Assisted
Immunohistochemistry
Liver
Liver Cirrhosis
Liver Diseases
Lung Diseases
Lung Diseases, Obstructive
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 8228125
DOI: 10.1016/s0168-8278(05)80275-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8228125-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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