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Article

The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease.

Journal of hepatology - 1 Jul 1993

Faber J P, Poller W, Olek K, Baumann U, Carlson J, Lindmark B, Eriksson S

Abstract excerpt

Alpha 1-antichymotrypsin (alpha 1-ACT) is a serine proteinase inhibitor (serpin) with cathepsin G, mast cell chymase and chymotrypsin as target enzymes. We present the case of a middle-aged man with low plasma levels of alpha 1-ACT, asthma with progression to emphysema, and chronic HCV positive liver disease with selective accumulation of alpha 1-ACT in hepatocytes. This secretory defect is analogous to that seen...

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Identifiers

PMID: 8228125
DOI: 10.1016/s0168-8278(05)80275-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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