Article
Differential S100 beta expression in choroidal and skin melanomas: quantitation by the polymerase chain reaction.
Investigative ophthalmology & visual science - 1 Nov 1993
Kan-Mitchell J, Liggett P E, Taylor C R, Rao N, Granada E S, Danenberg K D, White W L, Van Eldik L J, Horikoshi T, Danenberg P V
Abstract excerpt
PURPOSE: S100 beta, a member of a calcium-binding protein family (S100s), is an important clinical marker for skin melanoma. In contrast, uveal melanomas appeared to express S100 beta protein less frequently and to a lesser degree. This study was performed to verify and extend this finding to the mRNA level. METHODS: A quantitative polymerase chain reaction (PCR)-based method was used. A ratio, comparing the S100...
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