Article
Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement: clinical implications.
Cancer research - 1 Nov 1993
Jelinek D F, Ahmann G J, Greipp P R, Jalal S M, Westendorf J J, Katzmann J A, Kyle R A, Lust J A
Abstract excerpt
A new human myeloma cell line, ANBL-6, was established and characterized at the genotypic and phenotypic levels. The cells exhibit a clonally rearranged immunoglobulin gene locus and resemble plasma cells morphologically. The ANBL-6 cells also exhibited an absolute dependence on exogenous interleukin 6 for growth. Of interest, DNA ploidy analysis suggested the existence of a near-diploid as well as a...
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