Article
Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement: clinical implications.
Cancer research - 1 Nov 1993
Jelinek D F, Ahmann G J, Greipp P R, Jalal S M, Westendorf J J, Katzmann J A, Kyle R A, Lust J A
Abstract excerpt
A new human myeloma cell line, ANBL-6, was established and characterized at the genotypic and phenotypic levels. The cells exhibit a clonally rearranged immunoglobulin gene locus and resemble plasma cells morphologically. The ANBL-6 cells also exhibited an absolute dependence on exogenous interle...
Topics
- Aneuploidy
- Antigens, CD
- Antineoplastic Combined Chemotherapy Protocols
- Blotting, Southern
- Cell Division
- Cell Line
- Clone Cells
- Culture Techniques
- Cytokines
- DNA, Neoplasm
- Female
- Gene Rearrangement
- Genes, Immunoglobulin
- Genotype
- Humans
- Immunophenotyping
- Interleukin-6
- Karyotyping