Article
The effect of prenatal diazepam exposure on TNF-alpha production by rat splenocytes.
Agents and actions - 1 Mar 1993
Schreiber A A, Frei K, Lichtensteiger W, Schlumpf M
Abstract excerpt
Prenatal exposure to diazepam and other benzodiazepines (BDZ) has been found to result in a marked reduction of T-lymphocyte proliferation during postnatal development of rats. In search for pathogenic changes underlying this effect, we investigated the mitogen lipopolysaccharide (LPS) and concan...
Topics
- Animals
- Cell Division
- Cells, Cultured
- Concanavalin A
- Cytophotometry
- Diazepam
- Female
- Fluorescent Antibody Technique
- Lipopolysaccharides
- Lymphocytes
- Macrophages
- Male
- Phenotype
- Pregnancy
- Prenatal Exposure Delayed Effects
- Rats
- Spleen
- Tumor Necrosis Factor-alpha