Article
Do mutant woodchuck hepatitis viruses play a role in hepatocellular carcinogenesis?
Research in virology - 1 Jan 2000
Kew M C
Abstract excerpt
Although hepadnaviruses are implicated in the aetiology of hepatocellular carcinoma, the pathogenic mechanisms involved remain uncertain. Clonally propagated integrations of hepadnaviral DNA into cellular DNA can be demonstrated in most virally induced hepatocellular carcinomas. Integration occur...
Topics
- Animals
- Carcinoma, Hepatocellular
- DNA Topoisomerases, Type I
- DNA, Viral
- Gene Rearrangement
- Hepatitis B
- Hepatitis B Virus, Woodchuck
- Liver Neoplasms, Experimental
- Marmota
- Mutation
- Repetitive Sequences, Nucleic Acid
- Virus Integration