Article
Genetic changes in hepatitis delta virus from acutely and chronically infected woodchucks.
Journal of virology - 1 Jul 2006
Casey John L, Tennant Bud C, Gerin John L
Abstract excerpt
A woodchuck-derived hepatitis delta virus (HDV) inoculum was created by transfection of a genotype I HDV cDNA clone directly into the liver of a woodchuck that was chronically infected with woodchuck hepatitis virus. All woodchucks receiving this inoculum became positive for HDV RNA in serum, and 67% became chronically infected, similar to the rate of chronic HDV infection in humans. Analysis of HDV sequences...
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