Routes to repopulation--a unification of the stochastic model and separation of stem-cell subpopulations.

Article

Routes to repopulation--a unification of the stochastic model and separation of stem-cell subpopulations.

Leukemia - 1 Jun 1994

Gordon M Y, Blackett N M

Abstract excerpt

In summary, we propose that the haemopoietic system consists of a hierarchy of clonogenic stem and progenitor cells and that the stochastic effect is superimposed upon these compartments. This means that (i) considerable heterogeneity can exist within major compartments without the need to invoke...

Topics

Cell Cycle
Cell Division
Cell Separation
Genetic Variation
Hematopoietic Stem Cells
Humans
Models, Biological

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