Article
Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1994
Yim C Y, Hibbs J B, McGregor J R, Galinsky R E, Samlowski W E
Abstract excerpt
IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates. Glutathione, the major intracellular reductant, may become rate limiting to cytotoxic lymphocyte activation and proliferation under these circumstances. N-Acetyl cysteine (NAc-cys) was used to increase intracellular glutathione levels during lymphokine-activated killer (LAK) cell activation by IL-2. Incubation of...
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