Article
Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1994
Yim C Y, Hibbs J B, McGregor J R, Galinsky R E, Samlowski W E
Abstract excerpt
IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates. Glutathione, the major intracellular reductant, may become rate limiting to cytotoxic lymphocyte activation and proliferation under these circumstances. N-Acetyl cysteine (NAc-cys) was used to increase...
Topics
- Acetylcysteine
- Administration, Oral
- Animals
- Cytotoxicity, Immunologic
- Female
- Fibrosarcoma
- Glutathione
- Immunotherapy
- In Vitro Techniques
- Interleukin-2
- Killer Cells, Lymphokine-Activated
- Lymphocyte Activation
- Lymphocytes
- Male
- Mice
- Mice, Inbred C3H
- Phenotype