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Article

Comparative roles of histidine 51 in human beta 1 beta 1 and threonine 51 in pi pi alcohol dehydrogenases.

Archives of biochemistry and biophysics - 1 Jun 1994

Davis G J, Carr L G, Hurley T D, Li T K, Bosron W F

Abstract excerpt

Histidine at position 51 of the class I beta 1 alcohol dehydrogenase (ADH) functions as a general base by indirectly abstracting a proton from the alcohol substrate through a hydrogen-bonded proton relay system. The human class II pi-ADH was reported to be polymorphic, having either Ser or Thr, but not His at position 51. It is unknown whether Ser or Thr51 have a catalytic role in ethanol oxidation with pi-ADH....

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PMID: 8203892
DOI: 10.1006/abbi.1994.1242

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