The identification of <i>rofA</i>, a positive‐acting regulatory component of <i>prtF</i> expression: use of an mγδ‐based shuttle mutagenesis strategy in Streptococcus pyogenes

Abstract excerpt

Binding of the Gram-positive pathogenic bacterium Streptococcus pyogenes (group A streptococcus) to respiratory epithelium is mediated by the fibronectin-binding adhesin, protein F. Most strains of streptococci regulate the expression of protein F in response to oxygen levels and redox potential; however, JRS4 constitutively binds high levels of fibronectin under all environmental conditions. In this study, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Resistance in Staphylococcus
• Share to Infective Endocarditis Diagnosis and Management