Article
Founder effect: assessment of variation in genetic contributions among founders.
Human biology - 1 Apr 1994
O'Brien E, Kerber R A, Jorde L B, Rogers A R
Abstract excerpt
We present a Monte Carlo method for determining the distribution of founders' genetic contributions to descendant cohorts. The simulation of genes through known pedigrees generates the probability distributions of contributed genes in recent cohorts of descendants, their means, and their variance...
Topics
- Alleles
- Cohort Studies
- Female
- Gene Frequency
- Gene Pool
- Genetic Diseases, Inborn
- Genetic Variation
- Humans
- Male
- Monte Carlo Method
- Pedigree
- Racial Groups
- Reproduction
- Sexual Behavior
- United States