Article
Estimating the number of founder lineages from haplotypes of closely linked SNPs.
Molecular ecology - 1 Jun 2007
Leblois Raphaël, Slatkin Montgomery
Abstract excerpt
We consider an isolated population founded by a small number of individuals randomly chosen from a source population of known genetic composition at a known time in the past. We develop a Monte-Carlo maximum-likelihood method for estimating the number of founding individuals from the haplotype frequencies at several SNP (single nucleotide polymorphism) loci in a sample. We assume the isolated population was...
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