Article
Exonic variants of the GABA(B) receptor gene and panic disorder.
Psychiatric genetics - 1 Dec 2000
Sand P G, Godau C, Riederer P, Peters C, Franke P, Nöthen M M, Stöber G, Fritze J, Maier W, Propping P, Lesch K P, Riess O, Sander T, Beckmann H, Deckert J
Abstract excerpt
The enhancement of GABAergic neurotransmission has been closely linked to antipanic drug efficacy. This is the first study to investigate a putative association of exonic sequence variants of the human GABA(B) receptor 1 (GABA(B)R1) gene and susceptibility to panic disorder. Three DNA sequence variants in exons 1a1, 7 and 11 were assessed by polymerase chain reaction-based restriction fragment length polymorphism...
Topics
- Agoraphobia
- Alleles
- Amino Acid Substitution
- Case-Control Studies
- DNA
- Exons
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Germany
- Humans
- Male