Article
Exonic variants of the GABA(B) receptor gene and panic disorder.
Psychiatric genetics - 1 Dec 2000
Sand P G, Godau C, Riederer P, Peters C, Franke P, Nöthen M M, Stöber G, Fritze J, Maier W, Propping P, Lesch K P, Riess O, Sander T, Beckmann H, Deckert J
Abstract excerpt
The enhancement of GABAergic neurotransmission has been closely linked to antipanic drug efficacy. This is the first study to investigate a putative association of exonic sequence variants of the human GABA(B) receptor 1 (GABA(B)R1) gene and susceptibility to panic disorder. Three DNA sequence variants in exons 1a1, 7 and 11 were assessed by polymerase chain reaction-based restriction fragment length polymorphism...
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