Evidence for the secretion of thyrotropin with enhanced bioactivity in syndromes of thyroid hormone resistance.

doi:10.1210/jcem.78.5.8175956

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Article

Evidence for the secretion of thyrotropin with enhanced bioactivity in syndromes of thyroid hormone resistance.

The Journal of clinical endocrinology and metabolism - 1 May 1994

Persani L, Asteria C, Tonacchera M, Vitti P, Krishna V, Chatterjee K, Beck-Peccoz P

Abstract excerpt

Resistance to thyroid hormone (RTH) is a rare genetic disorder associated with diverse mutations in the thyroid hormone receptor beta-gene. TSH-dependent thyroid hyperstimulation, leading to goiter and elevated thyroid hormone levels, is a characteristic feature of RTH. However, about 60% of untr...

Topics

Adult
Child
Female
Goiter
Humans
Male
Middle Aged
Mutation
Receptors, Thyroid Hormone
Syndrome
Thyroid Hormones
Thyrotropin

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