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Article

High frequencies of human genetic diseases: founder effect with genetic drift or selection?

American journal of medical genetics - 1 Jan 1994

Zlotogora J

Abstract excerpt

Rare genetic diseases have been reported with high frequency in some populations. The mechanisms which were proposed to explain most of these observations include founder effect, genetic drift or selective advantage. In recent years, many genes have been sequenced and mutations causing some of these disorders were characterized. According to the analysis of haplotypes and/or mutations, it may be possible to...

Topics

Canada
Ethnicity
Finland
Gene Frequency
Genetic Diseases, Inborn
Genotype
Haplotypes
Humans
Jews
Louisiana
Mutation
Selection, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sweden

Source

Identifiers

PMID: 8172234
DOI: 10.1002/ajmg.1320490104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8172234-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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