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Article

Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468.

Cancer research - 1 May 1994

Avila M A, Velasco J A, Cansado J, Notario V

Abstract excerpt

The effects of the bioflavonoid quercetin (3,3',4',5,7-pentahydroxyflavone) on the growth and cell cycle progression of the human breast cancer cell line MDA-MB468 have been studied. Quercetin inhibited cell proliferation with an IC50 (a drug concentration which inhibited growth by 50% following a 3-day exposure) value of 7 micrograms/ml. In actively growing cultures, the addition of quercetin resulted in the...

Topics

Breast Neoplasms
Cell Cycle
Cell Division
Dose-Response Relationship, Drug
Down-Regulation
Female
Humans
Mutation
Quercetin
Tumor Cells, Cultured
Tumor Suppressor Protein p53

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PMID: 8162591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8162591-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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