Article
UBE2Q1 in a Human Breast Carcinoma Cell Line: Overexpression and Interaction with p53.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Shafiee Sayed Mohammad, Rasti Mozhgan, Seghatoleslam Atefeh, Azimi Tayebeh, Owji Ali Akbar
Abstract excerpt
The p53 tumor suppressor protein is a principal mediator of growth arrest, senescence, and apoptosis in response to a broad array of cellular damage. p53 is a substrate for the ubiquitin-proteasome system, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiquitination have not been well studied. UBE2Q1 is a novel E2 ubiquitin conjugating enzyme gene. Here, we investigated the effect of UBE2Q1...
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