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Article

Exploring molecular diversity with combinatorial shape libraries.

Trends in biochemical sciences - 1 Feb 1994

Kenan D J, Tsai D E, Keene J D

Abstract excerpt

Surface technologies based upon selection of ligands from combinatorial libraries herald a revolution in molecular research and drug discovery. Molecular diversity is generated by random combinations of monomeric building blocks to form polymeric conformers that constitute 'shape libraries'. The media for exploring surfaces of target molecules include synthetic or biological polymers consisting of natural or...

Topics

Antibodies
Biological Evolution
Gene Library
Genetic Techniques
Genetic Variation
Ligands
Nucleic Acids
Oligonucleotides
Protein Binding
RNA-Binding Proteins

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Identifiers

PMID: 8160266
DOI: 10.1016/0968-0004(94)90033-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8160266-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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