Detection of quantitative trait loci from frequency changes of marker alleles under selection.

doi:10.1017/s0016672300031906

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Article

Detection of quantitative trait loci from frequency changes of marker alleles under selection.

Genetical research - 1 Dec 1993

Keightley P D, Bulfield G

Abstract excerpt

A method was developed to estimate effects of quantitative trait loci (QTL) by maximum likelihood using information from changes of gene frequency at marker loci under selection, assuming an additive model of complete linkage between markers and QTL. The method was applied to data from 16 molecul...

Topics

Alleles
Animals
Gene Frequency
Genetic Linkage
Genetic Markers
Likelihood Functions
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Monte Carlo Method
Retroviridae
Selection, Genetic

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