Article
The spectrum of beta thalassaemia mutations in the UAE national population.
Journal of medical genetics - 1 Jan 1994
Quaife R, al-Gazali L, Abbes S, Fitzgerald P, Fitches A, Valler D, Old J M
Abstract excerpt
The beta thalassaemia alleles in 50 beta thalassaemia heterozygotes originating from many parts of the United Arab Emirates (UAE) have been characterised using the allele specific priming technique of the polymerase chain reaction (PCR). The IVSI-5 (G-->C) mutation was found to be present in 66%, while six other alleles occurred at the much lower frequencies of 2% to 8%. These were codon 8/9 (+G), IVSI-1, 3' end...
Topics
- Base Sequence
- DNA Primers
- Genetics, Population
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- United Arab Emirates
- beta-Thalassemia